Among lifestyle factors, which influence and aggravate common skin diseases, are obesity, smoking, and stress, poor health in general, poor diet and alcohol consumption. Among environmental causes, seasonal or climate changes are included, particularly those related to drastic changes in humidity. For eczema, the hypothesis is proposed that too sterile human environments can contribute to the development of allergies in children. In addition to this, it is suggested that dust mite allergy is obviously related to the disease. It is estimated that eczema affects about 10% of all human beings to varying degrees. In some areas, it is believed that the prevalence throughout life reaches up to one-third of the population, and it seems to be increasing over time. The eczema is characterized by dry and rough skins that can crack, and ooze in the most serious cases, have a look at the CBD Cure for Psoriasis!
Symptoms of dermatitis
There are several forms of dermatitis, the two most common forms being atopic or chronic dermatitis (eczema) and contactor acute dermatitis (caused by direct contact with an allergen or irritant, which is often mistaken for eczema). In general, the symptoms range from redness of the skin and hives to the eruption of blisters and lesions, in the most severe cases. Blisters and lesions can ooze and form crusts that can ultimately leave unsightly scars.
The most common symptoms are dry skin accompanied by intense itching. It is observed that, more frequently, the most affected areas are the ulnar and the popliteal fossa (the inner surface of the elbow and knees, respectively), the wrists, the hands and the face. Eczema produces a great weakness, but it is not mortal. However, in some cases, there has been evidence that the resulting infections have advanced through the injured skin causing fatalities. Infection caused by staphylococcal bacteria or streptococci is very common in eczema. In rare cases, it can cause a generalized infection and septicemia. In addition to this, the herpes simplex virus can infect the skin damaged by eczema and cause a very serious illness known as herpetic eczema, which in turn can cause bacterial systemic “superinfection” and even death.
Symptoms of psoriasis
Psoriasis also occurs in different forms, the most common being known as psoriasis vulgaris or plaque psoriasis. The “plates” of this terminology refer to inflammations of the skin (often more or less circular) and covered by a substance that looks like a plate of silvery scales. These plaques usually appear on the elbows, knees, scalp and back. Psoriasis Vulgaris affects up to 90% of psoriasis patients. There are other forms of pustular psoriasis, which causes lumps or pustules bulging, full of pus, accompanied by itching and sensitivity. Generally, the pustules appear on the hands and feet, or randomly throughout the body.
A rare, and potentially fatal, form of the disease is known as erythrodermic psoriasis. This disease, which produces a great weakness, can cause inflammation and exfoliation of most of the patient’s skin. The severity of the inflammation and skin loss may be such that the normal control of temperature regulation and barrier function is interrupted, irreparably, and may cause death.
Psoriasis involves inflammations, more or less circular, of dry skins that hardens and finally form scales that are then detached
Genetic influences on eczema and psoriasis
It has been discovered that patients with eczema present variations in the FLG gene, which encodes the expression of a protein known as filaggrin, which in turn is fundamental for the regulation of the stratum corneum, the outermost layer of the epidermis. The filagrinait binds to the free filaments of keratin and causes a matrix to form within the keratinocytes of the epidermis. This matrix, hard and impermeable, is the base of the impermeable “barrier” that forms the outer layer of human skin. It keeps the skin hydrated, both through the prevention of evaporation and through the absorption of water. It is also believed that variations in the FLG gene are involved in another debilitating skin disease, ichthyosis vulgaris, which causes the skin to acquire a scaly appearance due to the excessive production of keratinocytes. CBD Cure for Psoriasis works wonder!
Psoriasis, which also implies an excess production of keratinocytes, is closely related to genetic predisposition. About one-third of patients report family history of the disease! It is believed that several genes interact to determine the onset of psoriasis in ways that are not yet fully understood. Chromosomes have been found in around thirty-six different loci that correspond to susceptibility to psoriasis. The genes found within these loci participate in the inflammatory response, and several of them have been implicated in other autoimmune diseases, in addition to psoriasis.
Chronic skin diseases and the immune response
Both eczema and psoriasis involve an atypical immune response. It is considered that psoriasis is autoimmune in nature, since it does not occur due to any external allergen, but to a malfunctioning of the immune system that makes it attack tissue that was previously healthy. Eczema is a generalized response to the presence of external allergens, and is not an autoimmune disease, although it usually occurs in individuals suffering from other autoimmune diseases, and other specific forms of dermatitis have an autoimmune component. CBD Cure for Psoriasise is the best!
Specifically, eczema and psoriasis are diseases caused by the atypical inflammatory response. The inflammatory response is a fundamental part of the immune system: after initial exposure to a pathogen (or pathogen perceived in the case of an autoimmune disease such as psoriasis), plasma levels of blood and white blood cells (in particular, the granulocytes) increase and then arrive, through the bloodstream, to the affected tissues. These fluids accumulate, causing the characteristic swelling. The increased blood flow in the affected area causes redness and the sensation of heat and itching, and pain occurs due to the release of compounds that stimulate the nerve endings.
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